About Journal Author Guideline Sample Paper Copyright Form Plagiarism Report Current Issue Archive Issue Submit Paper Join as a Reviewer Editorial Board Contact Us

Volume 1 - Issue 1 - Papers

  • Antifertility Potential of Medicinal Plants: A Review

    Description: Various medicinal plant extracts have been tested for their Antifertility activity both in male and female animal models. This review presents the profiles of plants with Antifertility, reported in the literature. The profiles presented include information about the scientific name, family, the degree of Antifertility activity and the active agents. Totally 32 species are listed in the present review. Key Words: Antifertility activity, Medicinal plants.This review reveals that some plants and their part used having anti-fertility action, which are helpful for researcher to develop new herbal anti-fertility formulations. In the recent years, interest in drugs of plant origin has been progressively increased. The aim of this review is to highlight the work on anti-fertility of plant origin. We undertook an extensive bibliographic review by analysing peer reviewed papers, and further consulting well accepted worldwide scientific databases. Peer reviewed articles were gathered consulting the databases NISCAIR, SCOPUS, PUBMED and Google scholar using terms such as “antifertility”, “anti-implantation”, and “antispermatogenic” activity of plants. Plants, including their parts and extracts, that have traditionally been used to facilitate antifertility have been considered as antifertility agents. For women who can't use modern forms of contraception due to adverse effect or other reasons, therefore herbs can offer alternatives and reducing fertility would be better than other contraceptives. This review creates a solid foundation upon which to further study the efficacy of plants that are both currently used by women as traditional antifertility medicines, but also could be efficacious as an antifertility agent with additional research and study.

    Author: Geeta Devi Sahu

    Published: 19 Apr, 2025

    View Paper
  • Formulation and Evaluation of Floating Microsphere of Drug Lansoprazole

    Description: The present study was aimed to formulate and evaluate floating microspheres of lansoprazole. Theresearch work's objective was toretain lansoprazole in the stomach for a prolonged period of time, which hasabsorption window in the upper gastrointestinal tract. The buoyant microspheres will be preparedby using various composition of prescribe polymers. Result:-The drug (Lansoprazole) powder bulk and tapped densities to be 0.231 gm / cm3 and 0.238 gm / cm3, respectively. The particle size of unmilled powder was 101 μm. The partition coefficient of Lansoprazole was found to be 0.367and the value of partition coefficient of drug showed that the drug was lipophilic in nature. The Infrared spectra were obtainedusing an FTIR spectrometer. Solvent evaporation method was found suitable for preparation of microspheres. The yield obtained in all batches was good. The size of microsphere ranged between 36.45 µm to 39.86 µm of all polymer containing microspheres. Percent entrapment of drug was between 92.24-100.24% depending on the different polymers with polymer. The in-vitro buoyancy profile also shown that prepared microspheres buoyant more than 25% upto 12 hrs. Drug loaded microspheres containing calcium alginate shows 99.24-99.99% till to 24h but polymer ethylcellulose containing microspheres release 63.64-69.75% and egg albumin containing only 57.58-61.35% drug release. It seems drug only release after 12 h about 58.67% from capsular shell. Floating buoyant microspheres F2* was the best formulations was best formulation due on the basis of drug polymer combination in the ratio of 1:2 and stirring rate is 300 rpm.This as formulate the needful particle size for better retardant drug release upto 12 hr with better release profile.

    Author: Manisha Kumari

    Published: 16 Apr, 2025

    View Paper
  • Screening of phytochemicals and antipyretic activity of ethanolic extract of mesua ferrea

    Description: This study aimed to evaluate the antipyretic activity of the ethanolic extract of Mesua ferrea using a yeast-induced pyrexia model in rats and to analyze its phytochemical composition, focusing on bioactive compounds such as flavonoids and phenolic compounds. The ethanolic extract of Mesua ferrea was prepared, yielding 12.5% (w/w). Phytochemical analysis, including qualitative tests, thin-layer chromatography (TLC), total phenolic content (TPC), and total flavonoid content (TFC), was performed. The extract was rich in bioactive compounds, with a total phenolic content of 0.625mg/100mg and a total flavonoid content of 0.836mg/100mg. The analysis also identified quercetin, known for its anti-inflammatory and antioxidant properties. The ethanolic extract of Mesua ferrea exhibited significant antipyretic activity in a dose-dependent manner, with the higher dose (200mg/kg) showing effects comparable to paracetamol. The phytochemical analysis revealed a rich composition of flavonoids and phenolic compounds, suggesting their role in the observed antipyretic effects. These findings validate the traditional use of Mesua ferrea for fever management and highlight its potential as a natural alternative to conventional antipyretic drugs. Further studies are recommended to explore its mechanisms of action, safety profile, and clinical applications.

    Author: Manshi Dubey

    Published: 03 Apr, 2025

    View Paper
  • Development and Characterization of a Novel Controlled-Release Oral Dosage Form for Enhanced Bioavailability of Poorly Soluble Tamoxifen

    Description: Tamoxifen is widely used in the treatment of hormone receptor-positive breast cancer; however, its poor solubility in water significantly limits its bioavailability and therapeutic efficacy. This study aims to develop a novel controlled-release (CR) oral dosage form of Tamoxifen using advanced polymeric carriers to enhance its solubility and improve its pharmacokinetic profile. Various formulations were designed using Tamoxifen and different controlled-release polymers such as hydroxypropyl methylcellulose (HPMC), Eudragit RS100, and polyethylene glycol (PEG). In vitro dissolution, stability studies, and pharmacokinetic evaluation in an animal model were conducted. The results demonstrated that the CR formulation significantly improved the bioavailability and sustained the release of Tamoxifen over 24 hours, suggesting a promising approach for improving therapeutic outcomes in breast cancer therapy.

    Author: Dr. Sandeep Sahu

    Published: 03 Apr, 2025

    View Paper
  • Nanocarrier Liposome Based Targeting Of Rheumatoid Arthritis

    Description: About 1% of the world's population is affected by the chronic inflammatory disease rheumatoid arthritis (RA), which is also very morbid and significantly lethal. In order to minimise joint pain and inflammation, improve joint function, and stop joint damage and deformity, disease-modifying anti-rheumatic medications (DMARDs) are often used in combination with non-steroidal anti-inflammatory medicines (NSAIDs) and/or corticosteroids. Nanotechnology is the study and application of materials at the atomic, molecular, and supramolecular levels. In addition to improving the prospective therapeutic by lowering its toxicity and increasing its effectiveness, the development of nanomaterials for drug delivery may present new options for more targeted and precise molecular-level illness treatment. For the treatment of RA, liposomes have been thoroughly researched as drug delivery methods. Several key medications used to treat RA have low bioavailability, high clearance rates, and limited selectivity, necessitating high and frequent doses to achieve adequate therapeutic efficacy.

    Author: Dr. Amit Joshi

    Published: 02 Apr, 2025

    View Paper