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Screening of phytochemicals and antipyretic activity of ethanolic extract of mesua ferrea
Description: This study aimed to evaluate the antipyretic activity of the ethanolic extract of Mesua ferrea using a yeast-induced pyrexia model in rats and to analyze its phytochemical composition, focusing on bioactive compounds such as flavonoids and phenolic compounds. The ethanolic extract of Mesua ferrea was prepared, yielding 12.5% (w/w). Phytochemical analysis, including qualitative tests, thin-layer chromatography (TLC), total phenolic content (TPC), and total flavonoid content (TFC), was performed. The extract was rich in bioactive compounds, with a total phenolic content of 0.625mg/100mg and a total flavonoid content of 0.836mg/100mg. The analysis also identified quercetin, known for its anti-inflammatory and antioxidant properties. The ethanolic extract of Mesua ferrea exhibited significant antipyretic activity in a dose-dependent manner, with the higher dose (200mg/kg) showing effects comparable to paracetamol. The phytochemical analysis revealed a rich composition of flavonoids and phenolic compounds, suggesting their role in the observed antipyretic effects. These findings validate the traditional use of Mesua ferrea for fever management and highlight its potential as a natural alternative to conventional antipyretic drugs. Further studies are recommended to explore its mechanisms of action, safety profile, and clinical applications.
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Author: Manshi Dubey
Published: 03 Apr, 2025
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Development and Characterization of a Novel Controlled-Release Oral Dosage Form for Enhanced Bioavailability of Poorly Soluble Tamoxifen
Description: Tamoxifen is widely used in the treatment of hormone receptor-positive breast cancer; however, its poor solubility in water significantly limits its bioavailability and therapeutic efficacy. This study aims to develop a novel controlled-release (CR) oral dosage form of Tamoxifen using advanced polymeric carriers to enhance its solubility and improve its pharmacokinetic profile. Various formulations were designed using Tamoxifen and different controlled-release polymers such as hydroxypropyl methylcellulose (HPMC), Eudragit RS100, and polyethylene glycol (PEG). In vitro dissolution, stability studies, and pharmacokinetic evaluation in an animal model were conducted. The results demonstrated that the CR formulation significantly improved the bioavailability and sustained the release of Tamoxifen over 24 hours, suggesting a promising approach for improving therapeutic outcomes in breast cancer therapy.
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Author: Dr. Sandeep Sahu
Published: 03 Apr, 2025
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Nanocarrier Liposome Based Targeting Of Rheumatoid Arthritis
Description: About 1% of the world's population is affected by the chronic inflammatory disease rheumatoid arthritis (RA), which is also very morbid and significantly lethal. In order to minimise joint pain and inflammation, improve joint function, and stop joint damage and deformity, disease-modifying anti-rheumatic medications (DMARDs) are often used in combination with non-steroidal anti-inflammatory medicines (NSAIDs) and/or corticosteroids. Nanotechnology is the study and application of materials at the atomic, molecular, and supramolecular levels. In addition to improving the prospective therapeutic by lowering its toxicity and increasing its effectiveness, the development of nanomaterials for drug delivery may present new options for more targeted and precise molecular-level illness treatment. For the treatment of RA, liposomes have been thoroughly researched as drug delivery methods. Several key medications used to treat RA have low bioavailability, high clearance rates, and limited selectivity, necessitating high and frequent doses to achieve adequate therapeutic efficacy.
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Author: Dr. Amit Joshi
Published: 02 Apr, 2025
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